Oncology Central

Novel small molecule inhibitors of the OLIG2 transcription factor: promising new therapeutics for glioblastoma

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Approximately 10,000 new cases of glioblastoma (GBM) are diagnosed each year in the USA [1]. Most treatments are palliative in nature and do not alter the prognosis for the disease [2]. As a result, the median survival time is only about 15 months [3]. Even after extensive surgery to debulk the tumor, chemotherapy and radiation, the tumors invariably recur due to residual tumor-propagating cells that have been described as glioma stem-like cells (GSCs) [4,5].

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