Original Publication Date: 1 April, 2016
Publication / Source: Epigenomics
Authors: Jessica A Timms, Caroline L Relton, Judith Rankin, Gordon Strathdee & Jill A McKay
5-year survival rate for childhood acute lymphoblastic leukemia (ALL) has risen to approximately 90%, yet the causal disease pathway is still poorly understood. Evidence suggests multiple ‘hits’ are required for disease progression; an initial genetic abnormality followed by additional secondary ‘hits’. It is plausible that environmental influences may trigger these secondary hits, and with the peak incidence of diagnosis between 2 and 5 years of age, early life exposures are likely to be key.