Oncology Central

Potential of circulating tumor cells as blood-based biomarkers in cancer liquid biopsy


Despite the first reports of circulating cells from solid tumors shed light on the circulation in deceased and in living patients in 1869 [1] and the mid 1950s [2], respectively, it took almost 50 years until the introduction of the CellSearch® system by Veridex (now Janssen Diagnostics, LLC, Raritan, NJ, USA) as well as its approval by the US FDA [3] in 2004 paved the way for widespread clinical assessment of the number of circulating tumor cells (CTCs) as a prognostic diagnostic tool.

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