Oncology Central

Neurotrophic tyrosine kinase gene fusions: another opportunity for targeting in lung cancer

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Neurotrophic tyrosine kinase gene fusions

Neurotrophic tyrosine kinase (NTRK) genes encode for the Trk-family proteins: TrkA (encoded by NTRK1), TrkB (encoded by NTRK2) and TrkC (encoded by NTRK3). These family proteins normally play a role in the development of the CNS and PNS [1]. They modulate cells growth, proliferation, repair, maintenance and apoptosis [2]. Lately, NTRK fusions have been found in solid tumors creating oncogenic fusions responsible for transformation of cancer cells, proliferation and survival [3]. Several studies have documented how the presence of these three gene fusions is associate with worse survivals in all types of lung cancers [4].

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