Original Publication Date: 1 April, 2016
Publication / Source: Lung Cancer Management
Authors: Luis E Raez & Christian Rolfo
Neurotrophic tyrosine kinase gene fusions
Neurotrophic tyrosine kinase (NTRK) genes encode for the Trk-family proteins: TrkA (encoded by NTRK1), TrkB (encoded by NTRK2) and TrkC (encoded by NTRK3). These family proteins normally play a role in the development of the CNS and PNS . They modulate cells growth, proliferation, repair, maintenance and apoptosis . Lately, NTRK fusions have been found in solid tumors creating oncogenic fusions responsible for transformation of cancer cells, proliferation and survival . Several studies have documented how the presence of these three gene fusions is associate with worse survivals in all types of lung cancers .