Oncology Central

The end of the beginning: PD-1 inhibition as the new standard of care first-line immunotherapy in metastatic melanoma


Historically, treatment options for metastatic melanoma (MM) have been limited, yielding a median overall survival (OS) of 8–10 months and a 5-year survival of less than 10% [1]. These dismal results have been radically improved due to the dramatic advances in immunotherapy for MM. The immunotherapy revolution began with the CTLA-4 inhibitor ipilimumab (Bristol Myers-Squibb, NY, USA), the first medication to show an OS benefit in MM [2,3].

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