Original Publication Date: 20 January, 2016
Publication / Source: Immunotherapy
Authors: Ruben Hernandez-Alcoceba, Joanna Poutou, María Cristina Ballesteros-Briones & Cristian Smerdou
IL-12 is an immunostimulatory cytokine with strong antitumor properties. Systemic administration of IL-12 in cancer patients led to severe toxic effects, prompting the development of gene therapy vectors able to express this cytokine locally in tumors. Both nonviral and viral vectors have demonstrated a high antitumor efficacy in preclinical tumor models. Some of these vectors, including DNA electroporation, adenovirus and ex vivo transduced dendritic cells, were tested in patients, showing low toxicity and moderate antitumor efficacy.