Original Publication Date: 1 October, 2015
Publication / Source: Future Oncology
Authors: Mandeep S Sagoo, Aleksandra Filipovic, Lamis Al Harby & Justin Stebbing
Cancers of the eye are rare, but have become the paradigm for the study of rare malignancies. Retinoblastoma, the commonest intraocular malignancy of childhood occurs in one in 18,000 live births. It was one of the first cancers to be assigned a genetic basis, with Knudson’s double hit hypothesis . Whereas treatment was once limited to radiotherapy and/or surgical eye removal (enucleation), advances in chemotherapy have changed the treatment and prognosis of this tumor .