Original Publication Date: 1 January, 2016
Publication / Source: CNS Oncology
Authors: Simon S Lo, Kristin J Redmond, Eric L Chang et al
Whole brain radiotherapy (WBRT) has traditionally been the standard treatment for brain metastases . More recently, patients with limited brain metastases are being offered stereotactic radiosurgery (SRS), with or without WBRT, in an attempt to improve survival and functional outcomes. A recent editorial has suggested that the sun is setting on WBRT and SRS is rising to be the standard of care . This editorial summarizes the data from individual international randomized trials and a meta-analysis regarding the role of SRS in patients with limited brain metastases, and will focus on its role as a definitive therapy.
For patients with limited brain metastases, definitive local therapy in addition to WBRT has been demonstrated to improve local control and overall survival compared with WBRT alone [3–5]. In the Radiation Therapy Oncology Group (RTOG) 9508 trial, patients with 1–3 new brain metastases were randomized to WBRT alone or WBRT plus SRS.
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