Original Publication Date: 1 November, 2015
Publication / Source: Immunotherapy
Authors: De Yang, Michael Bustin & Joost J Oppenheim
Incipient cancer cells formed as a result of mutations of oncogene(s), tumor suppressor gene(s) and/or DNA repair gene(s) develop into malignant tumors depending on three processes. They acquire a higher rate of mutation due to increased sensitivity to endogenous and exogenous mutagenic agents or due to a breakdown in one or several components of the DNA repair machinery .