Original Publication Date: 1 September, 2015
Publication / Source: Epigenomics
Authors: Margherita Nannini, Gloria Ravegnini, Sabrina Angelini, Annalisa Astolfi, Guido Biasco & Maria A Pantaleo
MicroRNAs are a class of short noncoding RNAs, that play a relevant role in multiple biological processes, such as differentiation, proliferation and apoptosis. Gastrointestinal stromal tumors (GIST) are considered as a paradigm of molecular biology in solid tumors worldwide, and after the discovery of specific alterations in the KIT and PDGFRA genes, they have emerged from anonymity to become a model for targeted therapy.