Original Publication Date: 1 September, 2015
Publication / Source: Epigenomics
Authors: Kwan Yeung Wong & Chor Sang Chim
Multiple myeloma is an incurable hematological malignancy arising from immortalized plasma cells in the bone marrow. DNA methylation refers to the catalytic addition of a methyl group to the cytosine ring of a CpG dinucleotide. Methylation of a promoter-associated CpG island, a cluster of CpG dinucleotides, may lead to silencing of the associated gene.