Original Publication Date: 1 July, 2015
Publication / Source: CNS Oncology
Authors: Timothy H Ung, Hani Malone, Peter Canoll & Jeffrey N Bruce
Glioblastoma is the most common primary brain tumor in adults and carries a dismal prognosis despite advancements in treatment. Diffuse tumor infiltration precludes curative surgical resection and necessitates advancements in drug delivery mechanisms. Convection-enhanced delivery (CED) enables continuous local drug delivery for a diverse population of antitumor agents. Importantly, CED circumvents therapeutic challenges posed by the blood–brain barrier by facilitating concentrated local therapeutic drug delivery with limited systemic effects.