Original Publication Date: 1 September, 2015
Publication / Source: Immunotherapy
Authors: Steven N Seyedin, Jonathan E Schoenhals, Dean A Lee et al
Radiation therapy controls local disease but also prompts the release of tumor-associated antigens and stress-related danger signals that primes T cells to promote tumor regression at unirradiated sites known as the abscopal effect. This may be enhanced by blocking inhibitory immune signals that modulate immune activity through a variety of mechanisms. Indeed, abscopal responses have occurred in patients with lung cancer or melanoma when given anti-CTLA4 antibody and radiation.