Oncology Central

How endoplasmic reticulum stress contributes to obesity-driven hepatic tumorigenesis


Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. More than 90% of HCCs develop as a result of chronic liver disease, and chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is the main cause in most areas. However, several studies in Western countries showed that 30–40% of patients with HCC do not have chronic HBV or HCV infections [1]. Although this cluster includes alcoholic liver injury and some genetic liver diseases, such as hemochromatosis, other cases are more likely to be associated with obesity and metabolic syndrome and are considered to be based on nonalcoholic steatohepatitis (NASH).

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