Oncology Central

Regulatory T cells in cancer; can they be controlled?

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Natural regulatory T (Treg) cells, described as CD4+CD25+Foxp3+ cells have long been established as a subset of T lymphocytes critical for maintaining tolerance to self-constituents [1]. Their suppressive activities however extend beyond self tolerance as they have been demonstrated to regulate various facets of immune responses against allergens, microbial and infectious agents, as well as tissue-derived alloantigens [1]. Mounting evidence also shows their increased presence in cancer settings, often coinciding with attenuated antitumor T-cell responses [2].

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