Original Publication Date: 1 July, 2015
Publication / Source: Immunotherapy
Authors: Dennis O Adeegbe & Hiroyoshi Nishikawa
Natural regulatory T (Treg) cells, described as CD4+CD25+Foxp3+ cells have long been established as a subset of T lymphocytes critical for maintaining tolerance to self-constituents . Their suppressive activities however extend beyond self tolerance as they have been demonstrated to regulate various facets of immune responses against allergens, microbial and infectious agents, as well as tissue-derived alloantigens . Mounting evidence also shows their increased presence in cancer settings, often coinciding with attenuated antitumor T-cell responses .