Oncology Central

Gene delivery by a cationic and thermosensitive nanogel promoted established tumor growth inhibition

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Aim: In vivo stability and consequent high tumor accumulation is highly desired for nonviral gene therapy. Materials & methods: Here, a well-defined cationic nanogel system (NPS) was facilely prepared for gastric tumor therapy. Results: The physical chemical properties of NPS were finely regulated and investigated. In vitro transfer efficiency of NPS was obviously promoted due to stable polyplex structure, small size, narrow size distribution and weak surface potential. Interestingly, the transfection was further enhanced by its passive targeting function.

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