Original Publication Date: 1 May, 2015
Publication / Source: Pharmacogenomics
Authors: Neda Stjepanovic & Philippe L Bedard
Breast cancer is the most frequently diagnosed cancer in women worldwide and the second-leading cause of cancer-associated mortality . Current treatment for breast cancer is based upon the identification of patients whose tumors express the estrogen receptor (ER positive) and/or demonstrate gene amplification or protein overexpression of HER2/ERBB2 (HER2 positive). Advances in sequencing technology have enabled large-scale studies to elucidate the genomic landscape of breast cancer and other malignancies through The Cancer Genome Atlas  project.