Oncology Central

Elucidating the genomic landscape of breast cancer: how will this affect treatment?

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Breast cancer is the most frequently diagnosed cancer in women worldwide and the second-leading cause of cancer-associated mortality [1]. Current treatment for breast cancer is based upon the identification of patients whose tumors express the estrogen receptor (ER positive) and/or demonstrate gene amplification or protein overexpression of HER2/ERBB2 (HER2 positive). Advances in sequencing technology have enabled large-scale studies to elucidate the genomic landscape of breast cancer and other malignancies through The Cancer Genome Atlas [2] project.

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