Original Publication Date: 1 June, 2015
Publication / Source: Future Oncology
Authors: Donghai Xiong, Yian Wang & Ming You
PARK2 has tumor suppressive role in cancer
In general, Parkinson’s disease (PD) is a disease of older population. However, there are approximately 4% patients starting PD symptoms at age of 45 years or younger; and it is called early-onset Parkinson’s disease. PARK2 was identified as one of the causal factors of early-onset Parkinson’s disease that is under a recessive mode of inheritance .
PARK2 spans 1.36 Mb and comprises 12 small exons with a final processed transcript of 2.3 kb in size. Hence, the PARK2 gene is a typical example of extremely large genes encoding relatively small final processed transcripts.