Original Publication Date: 1 May, 2015
Publication / Source: Melanoma Management
Authors: Andrew J Muinonen-Martin & Robert H Insall
Early-stage cutaneous melanoma is curable but advanced, metastatic melanoma is almost uniformly fatal . Patients with such advanced disease have a short median survival of only 6–9 months . Not only is cutaneous melanoma responsible for 75–80% of skin cancer deaths but there is an ongoing ‘melanoma epidemic’ .
Detecting and excising melanoma early is key to improving survival and melanoma is characterized by clinical and biological heterogeneity, which in part explains why melanoma is notoriously resistant to chemo- and immuno-therapeutic strategies [4,5].