Oncology Central

Pulmonary adenocarcinoma with combined ALK translocation and copy number gain: a rare case with treatment response

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ALK gene rearrangements are detected by FISH, which also provides information on the ALK gene copy number per cell. ALK gene copy number gain (CNG) is a relative common finding in non-small-cell lung cancers; however, the clinical significance of ALK CNG is unclear. Here we reported a case of pulmonary adenocarcinoma that demonstrated combined ALK translocation and CNG, and provided clinical follow-up information including ALK inhibitor treatment responses.

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