Original Publication Date: 1 June, 2015
Publication / Source: Lung Cancer Management
Authors: Chen Zhang, Shadia Jalal, Shaobo Zhang, Mingsheng Wang & Liang Cheng
ALK gene rearrangements are detected by FISH, which also provides information on the ALK gene copy number per cell. ALK gene copy number gain (CNG) is a relative common finding in non-small-cell lung cancers; however, the clinical significance of ALK CNG is unclear. Here we reported a case of pulmonary adenocarcinoma that demonstrated combined ALK translocation and CNG, and provided clinical follow-up information including ALK inhibitor treatment responses.