Oncology Central

Pulmonary adenocarcinoma with combined ALK translocation and copy number gain: a rare case with treatment response


ALK gene rearrangements are detected by FISH, which also provides information on the ALK gene copy number per cell. ALK gene copy number gain (CNG) is a relative common finding in non-small-cell lung cancers; however, the clinical significance of ALK CNG is unclear. Here we reported a case of pulmonary adenocarcinoma that demonstrated combined ALK translocation and CNG, and provided clinical follow-up information including ALK inhibitor treatment responses.

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