Original Publication Date: 1 February, 2015
Publication / Source: Nanomedicine
Authors: Jennifer S Petschauer, Andrew J Madden, Whitney P Kirschbrown, Gina Song & William C Zamboni
Major advances in carrier-mediated agents, which include nanoparticles, nanosomes and conjugates, have revolutionized drug delivery capabilities over the past decade. While providing numerous advantages, such as greater solubility, duration of exposure and delivery to the site of action over their small-molecule counterparts, there is substantial variability in systemic clearance and distribution, tumor delivery and pharmacologic effects (efficacy and toxicity) of these agents.