Original Publication Date: 1 April, 2015
Publication / Source: Biomarkers in Medicine
Authors: Ioannis A Voutsadakis
The cancer stem cell hypothesis argues that cancers depend on a specific type of cells, representing usually a small percentage of the total cancer cell population, termed cancer stem cells (or tumor-initiating cells) for their development and propagation. In colorectal cancer these cells express specific surface proteins such as CD133 and CD44 and can recapitulate the whole tumor.