Original Publication Date: 1 April, 2015
Publication / Source: Hepatic Oncology
Authors: Jean Frédéric Blanc, Nora Frulio, Laurence Chiche, Paulette Bioulac-Sage & Charles Balabaud
Hepatocellular adenomas (HCAs) are composed of four molecular subgroups: mutations inactivating the HNF1A gene; the inflammatory phenotype with mutations of different genes leading to STAT3 activation; the activation of β-catenin by mutations in exon 3; among β-HCA, half display both inflammatory and β-catenin-activated phenotypes; and the unclassified tumors. The identification of these subtypes by MRI and immunohistochemistry on tissue is considered as a major criterion to manage patients.