Original Publication Date: 1 December, 2014
Publication / Source: Therapeutic Delivery
Authors: Ruman Rahman
Glioblastoma (GBM) is the most prevalent and aggressive malignant brain tumor with a median survival from diagnosis of 12–15 months. Standard-of-care treatment consists of radical surgery followed by radiotherapy with concomitant systemic temozolomide. Nevertheless, due to the infiltrative nature of GBM, this treatment strategy almost universally fails to eradicate minimal volume residual disease, which typically recurs within 2 cm from the original lesion .