Original Publication Date: 1 December, 2014
Publication / Source: Future Oncology
Authors: Hany A Omar, Mai F Tolba & Maha M Saber-Ayad
Unlike normal cells, cancer cells often shift their metabolism from oxidative phosphorylation to aerobic glycolysis as an adaptive response to intermittent hypoxia and the robust demand for energy production, the so-called Warburg effect described in 1924 . However, the high need of glucose and the lack of flexibility in modifying energy resources make cancer cells extremely vulnerable to glucose starvation and energy restriction [2,3].