Original Publication Date: 1 December, 2014
Publication / Source: Colorectal Cancer
Authors: Hemchandra Mahaseth & Anthony F Shields
Metastatic colorectal cancer is now commonly treated with doublet chemotherapy plus targeted chemotherapy and initially was used until progression or development of unacceptable toxicities. However, even in responding patients it is difficult to continue the treatment for more than 4–6 months due to toxicities, such as neutropenia, sensory neuropathy and asthenia or hand and foot syndrome.