Original Publication Date: 1 December, 2014
Publication / Source: International Journal of Hematologic Oncology
Authors: Hans-Peter Horny, Andreas Reiter, Karl Sotlar & Peter Valent
Mast cell leukemia (MCL) is a rare subtype of systemic mastocytosis. In MCL the numbers of mast cells exceed 19% of nucleated cells in bone marrow and/or 10% of circulating leukocytes in peripheral blood. Primary MCL must be distinguished from secondary MCL evolving from another subvariant of systemic mastocytosis or from mast cell sarcoma. Acute MCL with a poor prognosis is distinguished from the more indolent chronic MCL.