Original Publication Date: 1 November, 2014
Publication / Source: Epigenomics
Authors: Masayuki Komatsu, Hiroki Sasaki
Normal tissue stem cells possess the ability to produce a set of stem and progenitor cells by asymmetric cell division. Progenitor cells lose self-renewal ability but still can proliferate and convert to terminally differentiated cells. During such differentiation process, DNA methylation has a crucial role through epigenetic regulation of target gene expression at the right timing and environment. In other words, a cell population at each differentiation stage has an inherent DNA methylation profile.