Oncology Central

DNA methylation is a key factor in understanding differentiation phenotype in esophageal squamous cell carcinoma


Normal tissue stem cells possess the ability to produce a set of stem and progenitor cells by asymmetric cell division. Progenitor cells lose self-renewal ability but still can proliferate and convert to terminally differentiated cells. During such differentiation process, DNA methylation has a crucial role through epigenetic regulation of target gene expression at the right timing and environment. In other words, a cell population at each differentiation stage has an inherent DNA methylation profile.

Restricted Content / Members Only

You cannot view this content because It is available to members only. Please or Register to view this area.




News Headlines

Leave A Comment

Please wait...

Would you like access to more immuno-oncology content?

Register with Oncology Central to find out the latest news, opinions and journal articles published in the oncology field by leading experts.