Original Publication Date: 1 November, 2014
Publication / Source: Nanomedicine
Authors: Giuseppe Visani, Federica Loscocco, Alessandro Isidori
The major obstacle in treating cancer depends on the low therapeutic index of most anticancer drugs. The lack of specificity, coupled with the large volumes of distribution, translates into a nonpreferential distribution of anticancer drugs to the tumor. Accordingly, the dose of the anticancer drug that is achievable within tumor is limited, resulting in suboptimal treatment and unwanted toxicity.