Original Publication Date: 1 January, 2015
Publication / Source: Future Oncology
Authors: Monica Miozzo, Valentina Vaira, Silvia Maria Sirchia
Based on the pivotal importance of epigenetics for transcription regulation, it is not surprising that cancer is characterized by several epigenetic abnormalities. Conversely to genetic alterations, epigenetic changes are not permanent, thus represent opportunities for therapeutic strategies designed to reverse transcriptional abnormalities, and cancer is the first disease in which epigenetic therapies with chromatin remodeling agents were introduced.