Original Publication Date: 1 September, 2014
Publication / Source: Immunotherapy
Authors: Hans Anton Schlößer, Sebastian Theurich, Alexander Shimabukuro-Vornhagen et al
Mechanisms of tumor-mediated immunosuppression have been described for several solid and hematological tumors. Tumors inhibit immune responses by attraction of immunosuppressive lymphocytic populations, secretion of immunosuppressive cytokines or expression of surface molecules, which inhibit immune responses by induction of anergy or apoptosis in tumor-infiltrating lymphocytes. This tumor-mediated immunosuppression represents a major obstacle to many immunotherapeutic or conventional therapeutic approaches.