Original Publication Date: 1 July, 2014
Publication / Source: Biomarkers in Medicine
Authors: Hardev Pandha
Molecular changes in tissue adjacent to prostate cancer: a possible ‘carcinogenic filed effect’
Evaluation of: Crea F, Watahiki A, Quagliata L et al. Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. Oncotarget 15(3), 764–774 (2014).
Most transcribed RNAs are not translated so protein encoding genes account for a small percentage of all RNAs. The noncoding transcripts include ribosomal, transfer and microRNAs. A number of miRNAs have been proposed as potential biomarkers of PCa .
lncRNA transcripts longer than 200 base pairs have not been extensively evaluated, but have been associated with dysregulated expression in malignant cells. Some have purported tissue specificity: PCGEM1 and the better known PCA3. The latter has been extensively evaluated as a diagnostic test for PCa and also potentially an indicator of disease volume. PCA3 has not been able to distinguish between aggressive and indolent disease.