Original Publication Date: 1 August, 2014
Publication / Source: Colorectal Cancer
Authors: Nitya Raj, Leonard Saltz
Biologic agents are drugs that are made by living organisms. A number of these agents are now routinely used in the treatment of metastatic colorectal cancer. These biologic agents block aspects of specific signaling pathways. They are commonly presumed to have a more selective and targeted action in comparison to cytotoxic chemotherapy, although this assumption is not always borne out by data. These agents were developed with the goal of reducing the use of cytotoxic chemotherapy and thereby reducing the associated toxicities, however they are most commonly used concurrently with cytotoxics, and so the older toxicities often remain.