Original Publication Date: 1 August, 2014
Publication / Source: Colorectal Cancer
Authors: Julien Taieb, Aziz Zaanan
Microsatellite instability constitutes an important oncogenic molecular pathway in colon cancer (12–15%). Microsatellite instability is a molecular marker of deficient DNA mismatch repair (MMR), which occurs from somatic hypermethylation of the MLH1 promoter or less frequently as a result of germline mutations in MMR genes.