Oncology Central

Should mismatch repair status be determined in all stage II and III colon cancer patients?

0

Microsatellite instability constitutes an important oncogenic molecular pathway in colon cancer (12–15%). Microsatellite instability is a molecular marker of deficient DNA mismatch repair (MMR), which occurs from somatic hypermethylation of the MLH1 promoter or less frequently as a result of germline mutations in MMR genes.

To view restricted content, please:
Share:

Leave A Comment