Original Publication Date: 1 October, 2014
Publication / Source: Future Oncology
Authors: Marcello Maugeri-Saccà, Patrizia Vici, Luigi Di Lauro
Overcoming resistance to standard anticancer treatments represents a significant challenge. The interest regarding cancer stem cells, a cellular population that has the ability to self-renew and to propagate the tumor, was prompted by experimental evidence delineating the molecular mechanisms that are selectively activated in this cellular subset in order to survive chemotherapy. This has also stimulated combination strategies aimed at rendering cancer stem cells vulnerable to anticancer agents.