Oncology Central

Overcoming immune system evasion by personalized immunotherapy

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With the US FDA’s approval of the first cancer vaccine for prostate cancer [1] and immune checkpoint blockade therapy against CTLA-4 for melanoma [2], the complex interaction between antitumor immune responses and tumor immune evasion is being intensely scrutinized. Despite a number of exciting preclinical studies and clinical research, most novel immunotherapies have demonstrated limited efficacy in early-phase clinical trials. The reason for this is multifactorial.

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