Original Publication Date: 1 July, 2014
Publication / Source: Journal of Comparative Effectiveness Research
Authors: Vladimir Valakh, Curtis Miyamoto, Katsiaryna Mazurenka, Jeffrey C Liu
Aims: We retrospectively compared results of surgery alone (SX) or radiotherapy alone (RT) for early stage tonsil and base of tongue cancers. Materials & methods: Outcomes for 386 SX and 362 RT patients from Surveillance, Epidemiology and End Results database were analyzed using propensity covariate adjusted and inverse probability weighting models. Results: With median follow-up of 71 months, unadjusted overall survival at 5 years was 66.1% for SX versus 50.2% for RT (p < 0.001). Unadjusted cancer-specific survival was 80.9% for SX versus 67.3% for RT (p < 0.001). In multivariate analysis, treatment modality maintained association with overall survival and cancer-specific survival.