Oncology Central

Could targeting hormone receptors be an effective strategy in management of adrenal hyperplasia?


Cushing’s syndrome is classified into corticotropin-dependent and corticotropin-independent (i.e., primary adrenal) diseases. Bilateral adrenal hyperplasias, either micronodular or macronodular, represent a rare cause of primary adrenal Cushing’s syndrome, which occurs in less than 2% of all cases. Micronodular pigmented and nonpigmented hyperplasias are genetic conditions, which, in the great majority of cases, are the consequence of PRKAR1A and PDE11A (or PDE8B) gene-inactivating mutations.

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