Original Publication Date: 1 July, 2014
Publication / Source: Clinical Investigation
Authors: Edward L Nelson
This is the first of a comprehensive three-part review of the foundation for and therapeutic targeting of HER2/neu. No biological molecule in oncology has been more extensively or more successfully targeted than HER2/neu. This review will summarize the pertinent biology of HER2/neu and the EGF receptor family to which it belongs, with attention to the biological foundation for the design and clinical development of the entire range of HER2/neu-targeted therapies, including efforts to mitigate resistance mechanisms.