Original Publication Date: 1 June, 2014
Publication / Source: Colorectal Cancer
Authors: Haili Wang, Roman Eisner, Richard N Fedorak
Metabolomic-based tests for colorectal cancer
For an individual aged 50–74 years without a family or personal history of colorectal cancer, current population-based screening tools consist of a combination of a stool tests and/or a diagnostic imaging study. If colonic polyps are identified, these are then removed via colonoscopy. Each of these tests and combinations have advantages and limitations, the most important of which is the well-documented limited compliance with stool testing by individuals in addition to its limited diagnostic sensitivity. More recently, the concept of using a blood or urine metabolomics test to replace the stool test for detecting colonic polyps or cancer has been introduced and discussed in the literature .