Original Publication Date: 1 June, 2014
Publication / Source: International Journal of Hematologic Oncology
Authors: Christian Billard, Future Science Group
Deficiency in the apoptotic program is one of the hallmarks of chronic lymphocytic leukemia. Defective apoptosis mainly results from the constitutive activation of survival pathways, which leads to the transcription and overexpression of antiapoptotic factors. The latter include proteins of the Bcl-2 family and members of the IAP family.