Original Publication Date: 1 June, 2014
Publication / Source: Lung Cancer Management
Authors: Ming-Ching Lee, Daniel H Buitrago, Kyuichi Kadota, David R Jones, Prasad S Adusumilli
Micropapillary (MIP) histologic subtype included in the classification of lung adenocarcinomas (ADCs) is associated with both size- and stage-independent poor prognoses. MIP pattern in lung ADCs, even at small, early stages, correlates with high lymphovascular invasion, visceral pleural invasion and lymph node metastases. Recently, we reported that patients with a MIP component are at a higher risk of locoregional recurrence after limited resection.