Oncology Central

Therapeutic targeting of tumor-associated macrophages and microglia in glioblastoma

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Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor, accounting for approximately 15% of all primary brain tumors in adults. Despite therapeutic intervention involving surgical resection, ionizing irradiation (IR) and temozolomide, prognosis remains poor, with a median survival of 14.6 months, and a 5-year survival rate of only 3.3% [1]. Due in part to this dismal prognosis, GBM was one of the first diseases to be characterized by The Cancer Genome Atlas.

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