Original Publication Date: 1 June, 2014
Publication / Source: Pharmacogenomics
Authors: Gal Markel, Gilli Galore-Haskel, Ryan Sullivan
Evaluation of: Egberts F, Bergner I, Krüger S et al. Metastatic melanoma of unknown primary resembles the genotype of cutaneous melanomas Ann. Oncol. 25(1), 246–250 (2014).
In 1–8% of metastatic melanoma the primary tumor cannot be found. Although 90% of melanomas are of cutaneous origin, other origins exist. It has been proposed that the mutational status (i.e., BRAF, NRAS, KIT) can distinguish between different types of melanoma. Sixty-six melanomas of unknown primary origin from 44 melanoma patients were genotyped in order to identify the origin of the primary tumor and to evaluate the prognostic significance of mutational status.