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HOX genes: what their investigation could mean for acute myeloid leukemia

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Marc De Braekeleer, MD, PhD, is a Professor of Genetics at the Faculty of Medicine and Health Sciences of the University of Brest and Head of the Cytogenetics laboratory at the Brest University Hospital, France. He has published more than 100 peer-reviewed articles and reviews on hematologic malignancies. He is an active collaborator of the Atlas of Genetics and Cytogenetics in Oncology and Haematology.

Q What are HOX genes?

HOX (homeobox) genes are a group of related genes coding for a major class of transcription factors regulating many aspects of development. They are thought to originate from a hypothetical ProtoHox cluster of four genes duplicated early in animal evolution, giving rise to two twin clusters, the Hox cluster (class I homeobox genes) and the ParaHox cluster (class II homeobox genes) [1,2].

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