Oncology Central

PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma

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Constitutive activation of the PI3K pathway has been implicated in glioblastoma (GBM) pathogenesis. Pharmacologic inhibition can both inhibit tumor survival and downregulate expression of programmed death ligand-1, a protein highly expressed on glioma cells that strongly contributes to cancer immunosuppression.

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