Oncology Central

PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma


Constitutive activation of the PI3K pathway has been implicated in glioblastoma (GBM) pathogenesis. Pharmacologic inhibition can both inhibit tumor survival and downregulate expression of programmed death ligand-1, a protein highly expressed on glioma cells that strongly contributes to cancer immunosuppression.

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