Oncology Central

The emerging role of FGF receptor as a potential target in breast cancer


FGF receptor signaling & functions in the mammary gland

The FGF receptor (FGFR) signaling pathways have an important role in the development and differentiation of the human mammary gland [1]. The FGFRs are cell membrane bound receptor tyrosine kinases that are activated by binding FGF ligands. The FGFR family includes seven tyrosine kinase members (FGFR1b and c, FGFR2b and c, FGFR3b and c, and FGFR4) that bind FGFs selectively with different binding specificities leading to distinct biological actions [2]. In addition, there is FGFR5, which binds FGFs, but which lacks the intracellular tyrosine kinase domain. The FGF family comprises 22 members and 18 of them function as ligands for FGFRs. Interaction of FGFs with FGFR1–4 leads to the activation of intracellular signaling pathways, such as ERK–MAPK, PI3K and PLC pathways.

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