Original Publication Date: 1 May, 2014
Publication / Source: CNS ONcology
Authors: Vijay Ramaswamy, Nardin Samuel & Marc Remke
Medulloblastoma comprises the most common malignant childhood brain tumor. Recent genome-wide profiling approaches and next-generation sequencing studies have resulted in an improved understanding of the biological heterogeneity within this histopathological entity. Although previously considered one disease entity, on the basis of gene expression profiling, four core medulloblastoma subgroups have been defined: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4 [1–7]. Several integrated genomic studies have revealed that these subgroups also correlate with distinct patterns of somatic copy number alterations, recurrent somatic mutations, transcriptional and epigenetic signatures, patient demographics, clinical features and outcomes.