Oncology Central

Prognostic factors in chronic lymphocytic leukemia: a conceptual approach


Prognostic assessment is an essential component in the management of patients with chronic lymphocytic leukemia. Prognostic factors (e.g., clinical stage, lymphocyte doubling time and IGHV mutational status/ZAP70 expression), allow predicting time to disease progression and need of therapy and also provide a rough estimate of the overall survival. The most important predictor of survival in patients requiring intervention is response to therapy and its degree, patients with undetectable minimal residual disease following therapy having a much better outcome than those with an inferior response.

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