Original Publication Date: 1 April, 2014
Publication / Source: Clinical Investigation
Authors: Jiří Hatina
Cancer stem cells represent one of the dominant themes of cancer research today. Although not accepted by all and without reservation, and probably not valid for all tumors, the evidence for viewing tumors as a sort of aberrant tissue with intrinsic hierarchical organization is mounting. Cancer stem cells are placed at the top of this hierarchy, making them responsible for continuous tumor growth and progression. At the same time, they have several properties that make them difficult to eradicate by conventional therapeutic approaches.